Structure-activity analysis of guanidine group in agmatine for brain agmatinase.

  title={Structure-activity analysis of guanidine group in agmatine for brain agmatinase.},
  author={M Huang and Soundar Regunathan and Maurizio Botta and Kang-Bong Lee and Eric E McClendon and Gene B Yi and Michelle L Pedersen and David B Berkowitz and G. Q. Wang and Massimo Travagli and John E. Piletz},
  journal={Annals of the New York Academy of Sciences},
To identify a selective inhibitor of mammalian agmatinase, screening was performed on four analogues of agmatine with modifications directly to the guanidine group, six analogues with modifications to the carbon-amine chain, and one analogue with modifications at both ends of the molecule. Control compounds were aminoguanidine and 7-nitroindazole, known inhibitors of the three isoforms (i, e, n) of nitric oxide synthase (NOS), and arcaine, a known inhibitor of the glutamate NMDA receptor. These… CONTINUE READING

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