Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors.

@article{Burger2013StructureGO,
  title={Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors.},
  author={Matthew T. Burger and Wooseok Han and Jiong Lan and Gisele A Nishiguchi and Cornelia Bellamacina and Mika Lindval and Gordana Atallah and Yu Ding and Michelle Mathur and Chris McBride and Elizabeth L Beans and Kristine M Muller and Victoriano Tamez and Yanchen Zhang and Kay K Huh and Paul H Feucht and Tatiana Zavorotinskaya and Yumin Dai and Jocelyn Holash and Joseph Edward Castillo and John L. Langowski and Yingyun Wang and Min Chen and Pablo D{\'i}az Garc{\'i}a},
  journal={ACS medicinal chemistry letters},
  year={2013},
  volume={4 12},
  pages={1193-7}
}
Proviral insertion of Moloney virus (PIM) 1, 2, and 3 kinases are serine/threonine kinases that normally function in survival and proliferation of hematopoietic cells. As high expression of PIM1, 2, and 3 is frequently observed in many human malignancies, including multiple myeloma, non-Hodgkins lymphoma, and myeloid leukemias, there is interest in determining whether selective PIM inhibition can improve outcomes of these human cancers. Herein, we describe our efforts toward this goal. The… CONTINUE READING