Structure-Guided Mutations in the Terminal Organelle Protein MG491 Cause Major Motility and Morphologic Alterations on Mycoplasma genitalium

@inproceedings{Martinelli2016StructureGuidedMI,
  title={Structure-Guided Mutations in the Terminal Organelle Protein MG491 Cause Major Motility and Morphologic Alterations on Mycoplasma genitalium},
  author={Luca Martinelli and Luis Garc{\'i}a-Morales and Enrique Querol and Jaume Pi{\~n}ol and Ignacio Fita and B{\'a}rbara M Calisto},
  booktitle={PLoS pathogens},
  year={2016}
}
The emergent human pathogen Mycoplasma genitalium, with one of the smallest genomes among cells capable of growing in axenic cultures, presents a flask-shaped morphology due to a protrusion of the cell membrane, known as the terminal organelle, that is involved in cell adhesion and motility and is an important virulence factor of this microorganism. The terminal organelle is supported by a cytoskeleton complex of about 300 nm in length that includes three substructures: the terminal button, the… CONTINUE READING
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