Structure Governs the Deformability of Polymer Particles in a Microfluidic Blood Capillary Model

@inproceedings{Sun2015StructureGT,
  title={Structure Governs the Deformability of Polymer Particles in a Microfluidic Blood Capillary Model},
  author={Huanli Sun and Mattias Bj{\"o}rnmalm and Jiwei Cui and Edgar H H Wong and Yunlu Dai and Qiong Dai and Greg G Qiao and Frank Caruso},
  year={2015}
}
Particle stiffness is a design parameter that affects bionano interactions, including biodistribution kinetics and cellular processing. Herein, we develop soft polysaccharide (hyaluronic acid, HA) replica particles and capsules with tunable stiffness and sizes similar to human red blood cells (RBCs) via atom transfer radical polymerization-mediated continuous assembly of polymers (CAPATRP) and investigate their stiffness and deformability using colloidal-probe atomic force microscopy (CP-AFM… CONTINUE READING
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