Structure-Function Relationships of C-Reactive Protein in Bacterial Infection

  title={Structure-Function Relationships of C-Reactive Protein in Bacterial Infection},
  author={Donald Neba Ngwa and Alok Agrawal},
  journal={Frontiers in Immunology},
One host defense function of C-reactive protein (CRP) is to protect against Streptococcus pneumoniae infection as shown by experiments employing murine models of pneumococcal infection. The protective effect of CRP is due to reduction in bacteremia. There is a distinct relationship between the structure of CRP and its anti-pneumococcal function. CRP is functional in both native and non-native pentameric structural conformations. In the native conformation, CRP binds to pneumococci through the… Expand

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