Structure-Function Profile of MmpL3, the Essential Mycolic Acid Transporter from Mycobacterium tuberculosis.

@article{Belardinelli2016StructureFunctionPO,
  title={Structure-Function Profile of MmpL3, the Essential Mycolic Acid Transporter from Mycobacterium tuberculosis.},
  author={Juan Manuel Belardinelli and Amira Yazidi and Liang Yang and Lucien Fabre and Wei Li and Benoit Jacques and Shiva Kumar Angala and Isabelle Rouiller and Helen I Zgurskaya and Jurgen Sygusch and Mary Jackson},
  journal={ACS infectious diseases},
  year={2016},
  volume={2 10},
  pages={
          702-713
        }
}
The MmpL family of proteins translocates complex (glyco)lipids and siderophores across the cell envelope of mycobacteria and closely related Corynebacteriaceae and plays important roles in the biogenesis of the outer membrane of these organisms. Despite their significance in the physiology and virulence of Mycobacterium tuberculosis, and from the perspective of developing novel antituberculosis agents, little is known about their structure and mechanism of translocation. In this study, the… CONTINUE READING