Structure-Function Analysis of the Anopheles gambiae LRIM1/APL1C Complex and its Interaction with Complement C3-Like Protein TEP1

@inproceedings{Povelones2011StructureFunctionAO,
  title={Structure-Function Analysis of the Anopheles gambiae
                    LRIM1/APL1C Complex and its Interaction with Complement C3-Like Protein
                    TEP1},
  author={Michael Povelones and Leanna M. Upton and Katarzyna A. Sala and George K. Christophides},
  booktitle={PLoS pathogens},
  year={2011}
}
Malaria threatens half the world's population and exacts a devastating human toll. The principal malaria vector in Africa, the mosquito Anopheles gambiae, encodes 24 members of a recently identified family of leucine-rich repeat proteins named LRIMs. Two members of this family, LRIM1 and APL1C, are crucial components of the mosquito complement-like pathway that is important for immune defense against Plasmodium parasites. LRIM1 and APL1C circulate in the hemolymph exclusively as a disulfide… CONTINUE READING
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