Structure-Function Analyses of the Human SIX1–EYA2 Complex Reveal Insights into Metastasis and BOR Syndrome

@inproceedings{Patrick2013StructureFunctionAO,
  title={Structure-Function Analyses of the Human SIX1–EYA2 Complex Reveal Insights into Metastasis and BOR Syndrome},
  author={Aaron Patrick and Joshua Hunter Cabrera and Alastair L Smith and Xiaojiang S. Chen and Heide L. Ford and Rui Zhao},
  booktitle={Nature Structural &Molecular Biology},
  year={2013}
}
SIX1 interacts with EYA to form a bipartite transcription factor essential for mammalian development. Loss of function of this complex causes branchio-oto-renal (BOR) syndrome, whereas re-expression of SIX1 or EYA promotes metastasis. Here we describe the 2.0-Å structure of SIX1 bound to EYA2, which suggests a new DNA-binding mechanism for SIX1 and provides a rationale for the effect of BOR syndrome mutations. The structure also reveals that SIX1 uses predominantly a single helix to interact… CONTINUE READING
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