• DOI:10.1002/cbdv.201500071
Corpus ID: 44479628

Structure Elucidation, Antimicrobial and Cytotoxic Activities of a Halimane Isolated from Vellozia kolbekii Alves (Velloziaceae)

@article{Silva2015StructureEA,
  title={Structure Elucidation, Antimicrobial and Cytotoxic Activities of a Halimane Isolated from Vellozia kolbekii Alves (Velloziaceae)},
  author={C. Silva and Helv{\'e}cio M. Santos J{\'u}nior and Jussara P. Barbosa and Gisela L. Costa and Felipe A. R. Rodrigues and Denilson F. Oliveira and Let{\'i}cia V. Costa‐Lotufo and R. Alves and E. Eleutherio and Claudia M. Rezende},
  journal={Chemistry & Biodiversity},
  year={2015},
  volume={12}
}

C. Silva, Helvécio M. Santos Júnior, +7 authors Claudia M. Rezende

Published 2015

Chemistry, Medicine

Chemistry & Biodiversity

A new halimane diterpene was isolated from Vellozia kolbekii Alves (Velloziaceae) and identified as (5R,8R,9S,13R)‐halim‐1,10‐ene‐15,16‐diol (1). It showed cytotoxicity against three human cancer cell lines, SF‐295 (glioblastoma), MDA‐MB‐435 (melanoma), and HCT‐8 (colon adenocarcinoma). In the mechanism of cytotoxic action, halimane 1 interferes in two major phases of the cell cycle: in S phase, in which DNA synthesis occurs and where it is very sensitive to damage, and G2M phase which is the… CONTINUE READING

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