Structure Determinants of Lagunamide A for Anticancer Activity and Its Molecular Mechanism of Mitochondrial Apoptosis.

@article{Huang2016StructureDO,
  title={Structure Determinants of Lagunamide A for Anticancer Activity and Its Molecular Mechanism of Mitochondrial Apoptosis.},
  author={Xiaoxing Huang and W. Huang and L. Li and Xihuan Sun and Si-Yang Song and Qingyan Xu and Lianru Zhang and Bang-Guo Wei and X. Deng},
  journal={Molecular pharmaceutics},
  year={2016},
  volume={13 11},
  pages={
          3756-3763
        }
}
Marine natural products are served as attractive source of anticancer therapeutics, with the great success of "first-in-class" drugs, such as Yondelis, Halaven, and Brentuximab vendotin. Lagunamides A-C from marine cyanobacterium, Lyngbya majuscula, exhibit exquisite growth inhibitory activities against cancer cells. In this study, we have systematically investigated the structure-activity relationships (SARs) of a concise collection of lagunamide A and its analogues constructed by total… Expand
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