Structure-Based Drug Design of Small Molecule Peptide Deformylase Inhibitors to Treat Cancer.

@article{Gao2016StructureBasedDD,
  title={Structure-Based Drug Design of Small Molecule Peptide Deformylase Inhibitors to Treat Cancer.},
  author={Jian Gao and Tao Wang and Shengzhi Qiu and Yasheng Zhu and Li Liang and Youguang Zheng},
  journal={Molecules},
  year={2016},
  volume={21 4},
  pages={396}
}
Human peptide deformylase (HsPDF) is an important target for anticancer drug discovery. In view of the limited HsPDF, inhibitors were reported, and high-throughput virtual screening (HTVS) studies based on HsPDF for developing new PDF inhibitors remain to be reported. We reported here on diverse small molecule inhibitors with excellent anticancer activities designed based on HTVS and molecular docking studies using the crystal structure of HsPDF. The compound M7594_0037 exhibited potent… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
1 Citations
31 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 31 references

Synthesis and Biological Activity of 4H-Thieno[3,2-c]Chromene Derivatives

  • Y. P. Bogza, A. L. Katsiel, A. N. Sharypova, T. G. Tolstikova, A. S. Fisyuk
  • Chem. Heterocycl. Compd
  • 2015
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…