Structure-Based Dissection of the Natural Product Cyclopentapeptide Chitinase Inhibitor Argifin

@inproceedings{Andersen2008StructureBasedDO,
  title={Structure-Based Dissection of the Natural Product Cyclopentapeptide Chitinase Inhibitor Argifin},
  author={Ole Andreas Andersen and Amit Nathubhai and Mark J. Dixon and Ian M. Eggleston and Daan M F van Aalten},
  booktitle={Chemistry & biology},
  year={2008}
}
Chitinase inhibitors have chemotherapeutic potential as fungicides, pesticides, and antiasthmatics. Argifin, a natural product cyclopentapeptide, competitively inhibits family 18 chitinases in the nanomolar to micromolar range and shows extensive substrate mimicry. In an attempt to map the active fragments of this large natural product, the cyclopentapeptide was progressively dissected down to four linear peptides and dimethylguanylurea, synthesized using a combination of solution and solid… CONTINUE READING

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