Structure-Based Design of Inhibitors of Protein–Protein Interactions: Mimicking Peptide Binding Epitopes

@inproceedings{PelayGimeno2015StructureBasedDO,
  title={Structure-Based Design of Inhibitors of Protein–Protein Interactions: Mimicking Peptide Binding Epitopes},
  author={Marta Pelay-Gimeno and Adrian Glas and Oliver Koch and Tom N Grossmann},
  booktitle={Angewandte Chemie},
  year={2015}
}
Protein-protein interactions (PPIs) are involved at all levels of cellular organization, thus making the development of PPI inhibitors extremely valuable. The identification of selective inhibitors is challenging because of the shallow and extended nature of PPI interfaces. Inhibitors can be obtained by mimicking peptide binding epitopes in their bioactive conformation. For this purpose, several strategies have been evolved to enable a projection of side chain functionalities in analogy to… CONTINUE READING
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