• Corpus ID: 101186988

Structure Assignment of 8α-OH Phlegmariurine B——A Combined NMR and Density Functional Theory Investigation

  title={Structure Assignment of 8$\alpha$-OH Phlegmariurine B——A Combined NMR and Density Functional Theory Investigation},
  author={Tan Xiao},
  journal={Acta Chimica Sinica},
  • Tan Xiao
  • Published 2000
  • Chemistry
  • Acta Chimica Sinica
A combined NMR and density functional theory (B3LYP) investigation was carried out on a new alkaloid obtained from Huperzia serrata Thunb(Trev. ) . The theoretical NMR data of 8α- OH phlegmariurine B are in excellent agreement with the experimental results. The configuration was then established through analysis of the vicinal coupling constants and 2D NMR(NOESY and COSY) spectra.This work shows that the quantum chemistry study of NMR can serve as a promising tool in aiding structural… 
3 Citations
Huperzine A from Huperzia serrata: a review of its sources, chemistry, pharmacology and toxicology
Several HupA-related features are addressed in this review, including not only its therapeutic properties, but also its chemistry, biological and chemical sources, structure–activity relationship, pharmacokinetics and toxicology, which are discussed in detail covering the literature published from 1962 to 2014.
Huperzine A from Huperzia species--an ethnopharmacolgical review.
HupA has been marketed in China as a new drug for Alzheimer's disease (AD) treatment and its derivative ZT-1 is being developed as anti-AD new drug candidate both in China and in Europe.
Phytochemicals from fern species: potential for medicine applications
An updated review of the literature on the occurrence, chemotaxonomy and physiological activity of fern secondary metabolites is provided, covering recent findings concerning the bioactive phytochemicals and pharmacology of f Fern species.