Structure-Activity Study on Antiviral 5-Vinylpyrimidine Nucleoside Analogs Using Wiener's Topological Index

Abstract

The relationship between Wiener's topological index and the antiviral activity of a series of 5-vinylpyrimidine nucleoside analogs has been investigated. Values for more than 100 compounds were computed, and an active range was identified. The predicted activity of each compound was compared with reported antiviral activity against herpes simplex virus type… (More)
DOI: 10.1021/ci00020a021

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