Structure-Activity Relationship of Polyester-Based Cationic Polyrotaxane Vector-Mediated In Vitro siRNA Delivery: Effect on Gene Silencing Efficiency.

  title={Structure-Activity Relationship of Polyester-Based Cationic Polyrotaxane Vector-Mediated In Vitro siRNA Delivery: Effect on Gene Silencing Efficiency.},
  author={Sharwari Ghodke and Junaid N. Parkar and Aparna Deshpande and Prajakta P Dandekar and Ratnesh D Jain},
  journal={ACS applied bio materials},
  volume={3 11},
A series of linear polyester-based, α-cyclodextrin (CD)-threaded polyrotaxanes (PRTx) were synthesized for siRNA delivery. The investigation into the effect of the presence of polyester linkages in polyrotaxane established the structural-activity relationship between polyrotaxane and siRNA transfection efficiency. The ester-based polyrotaxane exhibited higher threading efficiency than poly(ethylene glycol)-based polyrotaxane. The threading efficiency is the driving force for transfection, as it… 
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