Structure-Activity Relationship and Substrate-Dependent Phenomena in Effects of Ginsenosides on Activities of Drug-Metabolizing P450 Enzymes

@article{Hao2008StructureActivityRA,
  title={Structure-Activity Relationship and Substrate-Dependent Phenomena in Effects of Ginsenosides on Activities of Drug-Metabolizing P450 Enzymes},
  author={Miao Hao and Yuqing Zhao and Peizhan Chen and He Huang and Hong Liu and Hualiang Jiang and Ruiwen Zhang and Hui Wang},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={259 - 274}
}
Ginseng, a traditional herbal medicine, may interact with several co-administered drugs in clinical settings, and ginsenosides, the major active components of ginseng, may be responsible for these ginseng-drug interactions (GDIs). Results from previous studies on ginsenosides' effects on human drug-metabolizing P450 enzymes are inconsistent and confusing. Herein, we first evaluated the inhibitory effects of fifteen ginsenosides and sapogenins on human CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4… CONTINUE READING

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