• Corpus ID: 14442132

Structure-Activity Relationship Investigation of Some New Tetracyclines by Electronic Index Methodology

  title={Structure-Activity Relationship Investigation of Some New Tetracyclines by Electronic Index Methodology},
  author={Fernando Sato and Scheila Furtado Braga and H{\'e}lio F. Dos Santos and Douglas Soares Galv{\~a}o},
  journal={arXiv: Biomolecules},
AbstractTetracyclines are an old class of molecules that constitute a broad-spectrum antibiotics. Since the first memberof tetracycline family were isolated, the clinical importance of these compounds as therapeutic and prophylacticagents against a wide range of infections has stimulated efforts to define their mode of action as inhibitors ofbacterial reproduction. We used three SAR methodologies for the analysis of biological activity of a set of 104tetracycline compounds. Our calculation were… 
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