Structure-(Dys)function relationships in mitochondrial electron transport chain complex II?

Abstract

It has been postulated that mitochondrially derived reactive oxygen species (ROS) play a major causative role in aging processes. The primary sources of these oxidants are believed to be complexes I and III of the electron transport chain, with little evidence supporting oxidant formation at complex II (succinate dehydrogenase). Mutation of a complex II… (More)

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