Structure—Activity Relationships of the Peptide Ile-Ala-Val-Pro and Its Derivatives Revealed Using the Semi-Empirical AM1 Method

@article{Pak2005StructureActivityRO,
  title={Structure—Activity Relationships of the Peptide Ile-Ala-Val-Pro and Its Derivatives Revealed Using the Semi-Empirical AM1 Method},
  author={Valeriy Viktorovich Pak and Min Seok Koo and N. Lee and Myung Sun Kim and Dae Kwon},
  journal={Chemistry of Natural Compounds},
  year={2005},
  volume={41},
  pages={454-460}
}
Several peptides with hypocholesterinemic properties were investigated in order to reveal structure-activity relationships. The semi-empirical AM1 method and molecular dynamics were used to determine common structural properties of these peptides. A mathematical model of the structure-activity relationship was obtained. According to this model, a hydrophobic part of these peptides is a required structural element for their biological activity. The proline acts as a key component in these… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-6 of 6 references

Istvan, Atheroscler. Suppl

  • E S.
  • 2003
1 Excerpt

The Organic Chemistry of Drug Design and Drug Action

  • R. B. Silverman
  • 1992
1 Excerpt

Kafarov, Optimization of Experiment in Chemistry and Chemical Technology [in Russian

  • V.V.S.L. Akhnazarov
  • Vysshaya Shkola, Moscow
  • 1978
1 Excerpt

J

  • R. V. Omkumar, V. W. Rodwell
  • Biol. Chem. , 269,
  • 1686

Biochem

  • E. S. Istvan, J. Deisenhofer
  • Biophys. Acta ,
  • 1529
1 Excerpt

and H

  • Z. H. Beg, J. A. Stonic
  • B. Brewer, Jr., . Biol. Chem. , 262,
  • 1322
1 Excerpt

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