Structure–activity relationships of synthetic progestins in a yeast-based in vitro androgen bioassay

  title={Structure–activity relationships of synthetic progestins in a yeast-based in vitro androgen bioassay},
  author={L. McRobb and D. Handelsman and R. Kazlauskas and S. Wilkinson and A. K. Heather},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  • L. McRobb, D. Handelsman, +2 authors A. K. Heather
  • Published 2008
  • Chemistry, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
  • The recent identification of tetrahydrogestrinone (THG), a non-marketed designer androgen used for sports doping but previously undetectable by established mass spectrometry-based urine drug screens, and its production by a facile chemical modification of gestrinone has raised concerns about the risks of developing designer androgens from numerous marketed progestins. We therefore have used yeast-based in vitro androgen and progesterone bioassays to conduct a structure-activity study assessing… CONTINUE READING
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