Structure–Pharmacokinetic Relationships in a Series of Valpromide Derivatives with Antiepileptic Activity

@article{HajYehia1989StructurePharmacokineticRI,
  title={Structure–Pharmacokinetic Relationships in a Series of Valpromide Derivatives with Antiepileptic Activity},
  author={Abdullah I. Haj-Yehia and Meir Bialer},
  journal={Pharmaceutical Research},
  year={1989},
  volume={6},
  pages={683-689}
}
The following valpromide (VPD) derivatives were synthesized and their structure–pharmacokinetic relationships explored: ethylbutylacetamide (EBD), methylpentylacetamide (MPD), propylisopropylacetamide (PID), and propylallylacetamide (PAD). In addition, the anticonvulsant activity of these compounds was evaluated and compared to that of VPD, valnoctamide (VCD), and valproic acid (VPA). MPD, the least-branched compound had the largest clearance and shortest half-life of all the amides… 

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