Structure–Function Analysis of the Herpes Simplex Virus Type 1 UL12 Gene: Correlation of Deoxyribonuclease Activityin Vitrowith Replication Function

@inproceedings{Henderson1998StructureFunctionAO,
  title={Structure–Function Analysis of the Herpes Simplex Virus Type 1 UL12 Gene: Correlation of Deoxyribonuclease Activityin Vitrowith Replication Function},
  author={Jeffrey O. Henderson and Lisa J. Ball-Goodrich and Deborah Sue Parris},
  year={1998}
}
Abstract Although the product of the UL12 gene of herpes simplex virus type 1 (HSV-1) has been shown to possess both exonuclease and endonuclease activities in vitro, and deletion of most of the gene within the viral genome results in inefficient production and maturation of infectious virions, the function of the deoxyribonuclease (DNase) activity per se in virus replication remains unclear. In order to correlate the in vitro and in vivo activities of the protein encoded by UL12, mutant… CONTINUE READING