Structure–Activity of Valencenoid Derivatives and Their Repellence to the Formosan Subterranean Termite

  title={Structure–Activity of Valencenoid Derivatives and Their Repellence to the Formosan Subterranean Termite},
  author={Betty C. R. Zhu and Gregg Henderson and Anne M. Sauer and Ying Yu and William E. Crowe and Roger A. Laine},
  journal={Journal of Chemical Ecology},
Eight valencenoid derivatives were evaluated for their repelling activity against Formosan subterranean termites, Coptotermes formosanus Shiraki. Among them, 1,10-dihydronootkatone was the strongest repellent, and valencene was the weakest. Results of the structure–repellency relationships indicated (1) reduction of the ketone group to the alcohol on position 2 of nootkatone curtailed the activity; (2) because of the low activity of valencene relative to nootkatone that the ketone group was… 
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12 of these plant-derived sesquiterpenes have been isolated, purified, and assayed for spatial and contact repellency against the yellow fever mosquito, Aedes aegypti, to develop quantitative structure-activity relationships that identified key properties of the sesQuiterpene molecule.
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(+)-Valencene and (+)-nootkatone are high value-added sesquiterpenoids found in grapefruit. The synthesis of (+)-nootkatone by chemical oxidation from (+)-valencene cannot meet the increasing demand


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Although the Robinson annelation of cis-4-isopropenyl-2-methylcyclohexanone with trans-pent-3-en-2-one affords (±)-nootkatone [4βH,5α-eremophila-1(10),11-dien-2-one] in low yield, the major product
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The topical, fumigant and ovicidal activity of fourteen monoter penoids and thirty-one monoterpenoid derivatives were evaluated using the house fly, Musca domestica to determine structure-activity relationships involving the monoterPenoids' structural shape, type of functional group, and degree of saturation.
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Several terpenoids and oils were screened for vapour toxicity and repellency against the termite, Odontotermes brunneus and among the compounds screened, eucalyptus oil produced the fastest knockdown while ß-ionone was found to be the least effective.
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The toxic and repellent properties of nine major constituents of essential oils, comprising benzene derivatives and terpenes, were evaluated against Periplaneta americana (L.). Contact and fumigant
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