Structure–Activity Relationships of Phenylalkylamines as Agonist Ligands for 5‐HT2A Receptors

  title={Structure–Activity Relationships of Phenylalkylamines as Agonist Ligands for 5‐HT2A Receptors},
  author={Antoni R. Blaazer and Pieter Smid and Chris G Dr Kruse},
Agonist activation of central 5‐HT2A receptors results in diverse effects, such as hallucinations and changes of consciousness. Recent findings indicate that activation of the 5‐HT2A receptor also leads to interesting physiological responses, possibly holding therapeutic value. Selective agonists are needed to study the full therapeutic potential of this receptor. 5‐HT2A ligands with agonist profiles are primarily derived from phenylalkylamines, indolealkylamines, and certain piperazines. Of… 

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