Structure‐Activity Studies on VIP: IV. The Synthetic Agonist Helodermin‐Fragment‐(1‐28)‐Amide Is a Potent VIP‐Agonist with Prolonged Duration of Tracheal Relaxant Activity

@article{Jaeger1996StructureActivitySO,
  title={Structure‐Activity Studies on VIP: IV. The Synthetic Agonist Helodermin‐Fragment‐(1‐28)‐Amide Is a Potent VIP‐Agonist with Prolonged Duration of Tracheal Relaxant Activity},
  author={E. Jaeger and S. Bauer and M. Joyce and H. Foda and H. Berisha and S. Said},
  journal={Annals of the New York Academy of Sciences},
  year={1996},
  volume={805}
}
An important role of vasoactive intestinal peptide (VIP; 1) as a regulator of airway function has been well recognized (for a recent review see reference 1). Besides other important features, VIP causes tracheobronchial relaxation and has potent anti-inflammatory actions. Therefore, it is an interesting candidate for the treatment of bronchial asthma, which could be administered by spray and inhalation. Such a clinical application is limited, however, by the rapid degradation of VIP by airway… Expand
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