Structure/function analysis of the invariant subunits of the T cell antigen receptor.

@article{Frank1991StructurefunctionAO,
  title={Structure/function analysis of the invariant subunits of the T cell antigen receptor.},
  author={Stuart J. Frank and Isaac Engel and Thomas Rutledge and F Letourneur},
  journal={Seminars in immunology},
  year={1991},
  volume={3 5},
  pages={299-311}
}
The T cell antigen receptor (TCR) is a multimeric surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response. The clonotypic nature of the TCR resides in the antigen binding TCR-alpha beta or TCR-gamma delta heterodimer. The CD3 complex of gamma, delta and epsilon and the zeta-family disulfide dimer comprise the invariant TCR chains. Assembly of the mature TCR complex requires specific subunit interactions, the detailed nature of… CONTINUE READING
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