Structure/function analysis of a critical disulfide bond in the active site of l-xylulose reductase

Abstract

l-Xylulose reductase (XR) is involved in water re-absorption and cellular osmoregulation. The crystal structure of human XR complemented with site-directed mutagenesis (Cys138Ala) indicated that the disulfide bond in the active site between Cys138 and Cys150 is unstable and may affect the reactivity of the enzyme. The effects of reducing agents on the… (More)
DOI: 10.1007/s00018-009-9065-y

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