Structure/antileishmanial activity relationship study of naphthoquinones and dependency of the mode of action on the substitution patterns.

@article{Ali2011StructureantileishmanialAR,
  title={Structure/antileishmanial activity relationship study of naphthoquinones and dependency of the mode of action on the substitution patterns.},
  author={Ahmadi Nayeb Ali and Andreana N. Assimopoulou and Vassilios P. Papageorgiou and Herbert Kolodziej},
  journal={Planta medica},
  year={2011},
  volume={77 18},
  pages={
          2003-12
        }
}
A series of naphthoquinones was tested for activity against both extracellular promastigote and intracellular amastigote Leishmania major GFP in vitro. In parallel, the compounds were evaluated for cytotoxic effects against bone marrow-derived macrophages (BMM Φ) as a mammalian host cell control. Most of the compounds noticeably inhibited the growth of extracellular parasites (IC (50) 0.5 to 6 µM) and the intracellular survival of L. major GFP amastigotes (IC (50) 1 to 7 µM) when compared with… 

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