Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation*

@article{Hacker2016StructureFunctionAO,
  title={Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation*},
  author={K. Hacker and Catherine C. Fahey and Stephen A. Shinsky and Yun-Chen J Chiang and Julia V DiFiore and D. Jha and Andy H. Vo and J. Shavit and I. Davis and B. Strahl and W. Rathmell},
  journal={The Journal of Biological Chemistry},
  year={2016},
  volume={291},
  pages={21283 - 21295}
}
The yeast Set2 histone methyltransferase is a critical enzyme that plays a number of key roles in gene transcription and DNA repair. Recently, the human homologue, SETD2, was found to be recurrently mutated in a significant percentage of renal cell carcinomas, raising the possibility that the activity of SETD2 is tumor-suppressive. Using budding yeast and human cell line model systems, we examined the functional significance of two evolutionarily conserved residues in SETD2 that are recurrently… Expand
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References

SHOWING 1-10 OF 65 REFERENCES
Identification and Characterization of a Novel Human Histone H3 Lysine 36-specific Methyltransferase*
Roles for Ctk1 and Spt6 in Regulating the Different Methylation States of Histone H3 Lysine 36
Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1.
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
...
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4
5
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