Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs


The thymine analog 5-chlorouridine, first reported in the 1950s as anti-tumor agent, is known as an effective mutagen, clastogen and toxicant as well as an effective inducer of sister-chromatid exchange. Recently, the first microorganism with a chemically different genome was reported; the selected Escherichia coli strain relies on the four building blocks… (More)
DOI: 10.1093/nar/gks1316