Structure, regulation and physiological roles of urea transporters.

  title={Structure, regulation and physiological roles of urea transporters.},
  author={Matthias A. Hediger and Craig P Smith and Guofeng You and W S Lee and Yoshikatsu Kanai and Chairat Shayakul},
  journal={Kidney international},
  volume={49 6},
Urea is the major constituent of the urine and the principal means for disposal of nitrogen derived from amino acid metabolism. Specialized phloretin-inhibitable urea transporters are expressed in kidney medulla and play a central role in urea excretion and water balance. These transporters allow accumulation of urea in the medulla and enable the kidney to concentrate urine to an osmolality greater than systemic plasma. Recently, expression cloning with Xenopus oocytes has led to the isolation… CONTINUE READING

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