Structure, mechanism and catalytic duality of thiamine-dependent enzymes

  title={Structure, mechanism and catalytic duality of thiamine-dependent enzymes},
  author={Ren{\'e} Frank and Finian J Leeper and Ben F Luisi},
  journal={Cellular and Molecular Life Sciences},
Thiamine is an essential cofactor that is required for processes of general metabolism amongst all organisms, and it is likely to have played a role in the earliest stages of the evolution of life. Here, we review from a structural perspective the enzymatic mechanisms that involve this cofactor. We explore asymmetry within homodimeric thiamine diphosphate (ThDP)-dependent enzyme structures and discuss how this may be correlated with the kinetic properties of half-of-the-sites reactivity, and… CONTINUE READING
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