Structure, inhibition, and regulatory sites of TPC1 from Arabidopsis thaliana

  title={Structure, inhibition, and regulatory sites of TPC1 from Arabidopsis thaliana},
  author={Alexander F Kintzer and Robert Michael Stroud},
Two-pore channels (TPCs) comprise a subfamily (TPC1–3) of eukaryotic voltage- and ligand-gated cation channels with two non-equivalent tandem pore-forming subunits that dimerize to form quasi-tetramers. Found in vacuolar or endolysosomal membranes, they regulate the conductance of sodium and calcium ions, intravesicular pH, trafficking and excitability. TPCs are activated by a decrease in transmembrane potential and an increase in cytosolic calcium concentrations, are inhibited by low luminal… CONTINUE READING
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