Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD.

@article{GrandeGarca2014StructureFC,
  title={Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD.},
  author={Araceli Grande-Garc{\'i}a and Nada Lallous and Celsa D{\'i}az-Tejada and Santiago Ram{\'o}n-Maiques},
  journal={Structure},
  year={2014},
  volume={22 2},
  pages={185-98}
}
Upregulation of CAD, the multifunctional protein that initiates and controls the de novo biosynthesis of pyrimidines in animals, is essential for cell proliferation. Deciphering the architecture and functioning of CAD is of interest for its potential usage as an antitumoral target. However, there is no detailed structural information about CAD other than that it self-assembles into hexamers of ∼1.5 MDa. Here we report the crystal structure and functional characterization of the dihydroorotase… CONTINUE READING
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Phylogenetic analysis and classification of dihydroorotases: a complex history for a complex enzyme

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  • Paths Pyrimidines
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