Structure, function and toxicity of alpha‐synuclein: the Bermuda triangle in synucleinopathies

  title={Structure, function and toxicity of alpha‐synuclein: the Bermuda triangle in synucleinopathies},
  author={Anna Villar-Piqu{\'e} and Tom{\'a}s Lopes da Fonseca and Tiago Fleming Outeiro},
  journal={Journal of Neurochemistry},
Parkinson's disease belongs to a group of currently incurable neurodegenerative disorders characterized by the misfolding and accumulation of alpha‐synuclein aggregates that are commonly known as synucleinopathies. Clinically, synucleinopathies are heterogeneous, reflecting the somewhat selective neuronal vulnerability characteristic of each disease. The precise molecular underpinnings of synucleinopathies remain unclear, but the process of aggregation of alpha‐synuclein appears as a central… 
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  • R. Melki
  • Biology
    Journal of Parkinson's disease
  • 2015
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