Structure, function and toxicity of alpha‐synuclein: the Bermuda triangle in synucleinopathies

@article{VillarPiqu2016StructureFA,
  title={Structure, function and toxicity of alpha‐synuclein: the Bermuda triangle in synucleinopathies},
  author={A. Villar-Piqu{\'e} and Tom{\'a}s Lopes da Fonseca and T. Outeiro},
  journal={Journal of Neurochemistry},
  year={2016},
  volume={139}
}
Parkinson's disease belongs to a group of currently incurable neurodegenerative disorders characterized by the misfolding and accumulation of alpha‐synuclein aggregates that are commonly known as synucleinopathies. Clinically, synucleinopathies are heterogeneous, reflecting the somewhat selective neuronal vulnerability characteristic of each disease. The precise molecular underpinnings of synucleinopathies remain unclear, but the process of aggregation of alpha‐synuclein appears as a central… Expand
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