Structure, function and evolution of the signal recognition particle.

  title={Structure, function and evolution of the signal recognition particle.},
  author={Kiyoshi Nagai and Chris Oubridge and Andreas Kuglstatter and Elena Menichelli and Catherine Isel and Luca Jovine},
  journal={The EMBO journal},
  volume={22 14},
The signal recognition particle (SRP) is a ribonucleoprotein particle essential for the targeting of signal peptide-bearing proteins to the prokaryotic plasma membrane or the eukaryotic endoplasmic reticulum membrane for secretion or membrane insertion. SRP binds to the signal peptide emerging from the exit site of the ribosome and forms a ribosome nascent chain (RNC)-SRP complex. The RNC-SRP complex then docks in a GTP-dependent manner with a membrane-anchored SRP receptor and the protein is… CONTINUE READING