Structure, function and clinical significance of transferrin receptors.

@article{Feelders1999StructureFA,
  title={Structure, function and clinical significance of transferrin receptors.},
  author={Richard A. Feelders and Ellen P. A. Kuiper-Kramer and Henk G. van Eijk},
  journal={Clinical chemistry and laboratory medicine},
  year={1999},
  volume={37 1},
  pages={
          1-10
        }
}
Iron plays an essential role in a spectrum of metabolic processes. Cellular iron uptake is facilitated by transferrin receptor (TfR)-mediated endocytosis. In recent years more insight has been obtained in TfR physiology and the regulation of cellular iron homeostasis. The synthesis of TfR and the iron storage protein ferritin is regulated reciprocally at the post-transcriptional level according to the cellular iron status. As a result of externalization of TfR during the endocytic cycle, a… CONTINUE READING

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