Structure, function and biology of tissue factor pathway inhibitor-2.

  title={Structure, function and biology of tissue factor pathway inhibitor-2.},
  author={Hitendra S Chand and Donald C. Foster and W. Jake Kisiel},
  journal={Thrombosis and haemostasis},
  volume={94 6},
Tissue factor pathway inhibitor-2 (TFPI-2) is a 32 kDa matrix-associated Kunitz-type serine proteinase inhibitor consisting of a short amino-terminal region,three tandem Kunitz-type domains and a positively charged carboxy-terminal tail. Human TFPI-2, previously designated as placental protein 5, inhibits a broad spectrum of serine proteinases almost exclusively through its first Kunitz-type domain, and is thought to play an important role in the regulation of extracellular matrix digestion and… CONTINUE READING


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