Structure, function, and trafficking of SLC4 and SLC26 anion transporters.

@article{Cordat2014StructureFA,
  title={Structure, function, and trafficking of SLC4 and SLC26 anion transporters.},
  author={Emmanuelle Cordat and Reinhart A. F. Reithmeier},
  journal={Current topics in membranes},
  year={2014},
  volume={73},
  pages={
          1-67
        }
}
The structure and function of the red cell anion exchanger 1 (AE1, Band 3, SLC4A1), the truncated kidney anion exchanger 1 (kAE1), and the other members of the SLC4 family of bicarbonate transporters are reviewed. Mutations in the AE1 gene cause human diseases like Southeast Asian ovalocytosis and hereditary spherocytosis in the red cell and distal renal tubular acidosis in the kidney. These mutations affect the folding, trafficking, and functional expression of these membrane glycoproteins. In… CONTINUE READING
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