Structure, function, and pharmacology of acid-sensing ion channels (ASICs): focus on ASIC1a.

@article{Grnder2010StructureFA,
  title={Structure, function, and pharmacology of acid-sensing ion channels (ASICs): focus on ASIC1a.},
  author={Stefan Gr{\"u}nder and Xuanmao Chen},
  journal={International journal of physiology, pathophysiology and pharmacology},
  year={2010},
  volume={2 2},
  pages={73-94}
}
Acid-sensing ion channels (ASICs) are H(+)-gated Na(+) channels, which are present in most, if not all, neurons. The typical ASIC current is transient and is elicited by a rapid drop in the extracellular pH. In the human genome, four genes for ASICs are present: asic1 - 4. In this review, we will focus on ASIC1a, one of the key subunits in the central nervous system. We will describe the structure of this channel, a topic that has enormously profited from the recent elucidation of the first… CONTINUE READING