Structure, function, and immune properties of reassociated islet cells.

@article{Shizuru1985StructureFA,
  title={Structure, function, and immune properties of reassociated islet cells.},
  author={Judith A Shizuru and D K Trager and Ronald C. Merrell},
  journal={Diabetes},
  year={1985},
  volume={34 9},
  pages={898-903}
}
Rat islets were mechanically dissociated to single cells and allowed to form aggregates by rotation-mediated cell-cell interaction. The aggregates, or neoislets, demonstrated insulin release in response to 20 mM glucose and 10 mM theophylline that was comparable to that of intact islets cultured for a similar time. However, basal insulin release was considerably greater than that from freshly isolated islets. The microscopic structure of the neoislets revealed sorting into a B-cell domain at… CONTINUE READING