Structure, expression and function of a schwannoma-derived growth factor

@article{Kimura1990StructureEA,
  title={Structure, expression and function of a schwannoma-derived growth factor},
  author={Hideo Kimura and Wolfgang H. Fischer and David R. Schubert},
  journal={Nature},
  year={1990},
  volume={348},
  pages={257-260}
}
DURING the development of the nervous system, cells require growth factors that regulate their division and survival. To identify new growth factors, serum-free growth-conditioned media from many clonal cell lines1 were screened for the presence of mitogens for central nervous system glial cells. A cell line secreting a potent glial mitogen was established from a tumour (or 'schwannoma') derived from the sheath of the sciatic nerve. The cells of the tumour, named JS1 cells, were adapted to… 
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