Structure, expression, and function of kynurenine aminotransferases in human and rodent brains

@article{Han2009StructureEA,
  title={Structure, expression, and function of kynurenine aminotransferases in human and rodent brains},
  author={Qian Han and Tao Cai and Danilo A. Tagle and Junsuo S Li},
  journal={Cellular and Molecular Life Sciences},
  year={2009},
  volume={67},
  pages={353-368}
}
Kynurenine aminotransferases (KATs) catalyze the synthesis of kynurenic acid (KYNA), an endogenous antagonist of N-methyl-d-aspartate and alpha 7-nicotinic acetylcholine receptors. Abnormal KYNA levels in human brains are implicated in the pathophysiology of schizophrenia, Alzheimer’s disease, and other neurological disorders. Four KATs have been reported in mammalian brains, KAT I/glutamine transaminase K/cysteine conjugate beta-lyase 1, KAT II/aminoadipate aminotransferase, KAT III/cysteine… CONTINUE READING

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