Structure, diversity, and evolution of the T-cell receptor VB gene repertoire in primates

@article{Jaeger1994StructureDA,
  title={Structure, diversity, and evolution of the T-cell receptor VB gene repertoire in primates},
  author={Emma E. M. Jaeger and Ronald Bontrop and Jerry S. S. Lanchbury},
  journal={Immunogenetics},
  year={1994},
  volume={40},
  pages={184-191}
}
AB T-cell receptors (TCR) that recognize major histocompatibility complex (MHC)/peptide antigen complexes regulate humoral and cellular arms of the adaptive immune response. Antigen binding sites of MHC and immunoglobulin heavy chain variable regions(Igh-V) are subject to diversity enhancing selection. We sought to establish whether positive Darwinian selection has driven diversity of TCRBV chains in the primate lineage by sequencing rearranged TCR from rhesus monkeys and chimpanzees and… CONTINUE READING

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Characterisation of a novel human T cell receptor [3 chain variable region family by transpecies DNA hybridisation

M. A. Hall, E.E.M. Jaeger, R. E. Bontrop, J. S. Lanchbury
  • Eur J ImmunoI
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