Structure, bioactivity, and resistance mechanism of streptomonomicin, an unusual lasso Peptide from an understudied halophilic actinomycete.

@article{Metelev2015StructureBA,
  title={Structure, bioactivity, and resistance mechanism of streptomonomicin, an unusual lasso Peptide from an understudied halophilic actinomycete.},
  author={Mikhail Metelev and Jonathan I. Tietz and Joel Oliver Melby and Patricia M Blair and Lingyang Zhu and Itamar Livnat and Konstantin Severinov and Douglas A. Mitchell},
  journal={Chemistry & biology},
  year={2015},
  volume={22 2},
  pages={
          241-50
        }
}
Natural products are the most historically significant source of compounds for drug development. However, unacceptably high rates of compound rediscovery associated with large-scale screening of common microbial producers have resulted in the abandonment of many natural product drug discovery efforts, despite the increasing prevalence of clinically problematic antibiotic resistance. Screening of underexplored taxa represents one strategy to avoid rediscovery. Herein we report the discovery… CONTINUE READING
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Discovery and characterization of a novel C-terminal peptide carboxyl methyltransferase in a lassomycin-like lasso peptide biosynthetic pathway

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