Structure, G Protein Activation, and Functional Relevance of the Cardiac G Protein‐Gated K+ Channel, IKACh

@article{Wickman1999StructureGP,
  title={Structure, G Protein Activation, and Functional Relevance of the Cardiac G Protein‐Gated K+ Channel, IKACh},
  author={K. Wickman and G. Krapivinsky and S. Corey and M. Kennedy and J. Němec and I. Medina and D. Clapham},
  journal={Annals of the New York Academy of Sciences},
  year={1999},
  volume={868}
}
  • K. Wickman, G. Krapivinsky, +4 authors D. Clapham
  • Published 1999
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • ABSTRACT: The muscarinic‐gated atrial potassium channel IKACh has been well characterized functionally, and has been an excellent model system for studying G protein/effector interactions. Complementary DNAs encoding the composite subunits of IKACh have been identified, allowing direct probing of structural and functional features of the channel. Here, we highlight recent approaches taken in our laboratory to determine the oligomeric structure of native cardiac IKACh, the mechanism of… CONTINUE READING
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    References

    SHOWING 1-10 OF 51 REFERENCES
    Number and Stoichiometry of Subunits in the Native Atrial G-protein-gated K+ Channel, IKACh *
    • 108
    • PDF
    Atrial G protein-activated K+ channel: expression cloning and molecular properties.
    • 341
    • PDF
    Na+ activation of the muscarinic K+ channel by a G-protein-independent mechanism
    • 118
    • PDF
    Muscarine-gated K+ channel: subunit stoichiometry and structural domains essential for G protein stimulation.
    • 35