Structure, Function, and Modulation of GABAA Receptors*

@inproceedings{Sigel2012StructureFA,
  title={Structure, Function, and Modulation of GABAA Receptors*},
  author={Erwin Sigel and Michael E. Steinmann},
  year={2012}
}
The GABAA receptors are the major inhibitory neurotransmitter receptors in mammalian brain. Each isoform consists of five homologous or identical subunits surrounding a central chloride ion-selective channel gated by GABA. How many isoforms of the receptor exist is far from clear. GABAA receptors located in the postsynapticmembranemediate neuronal inhibition that occurs in the millisecond time range; those located in the extrasynaptic membrane respond to ambient GABA and confer long-term… CONTINUE READING

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