Structure, Function, and Mechanism of Progranulin; the Brain and Beyond

@article{Toh2011StructureFA,
  title={Structure, Function, and Mechanism of Progranulin; the Brain and Beyond},
  author={Huishi Toh and Babykumari P. Chitramuthu and Hugh P. J. Bennett and Andrew Bateman},
  journal={Journal of Molecular Neuroscience},
  year={2011},
  volume={45},
  pages={538-548}
}
Mutation of human GRN, the gene encoding the secreted glycoprotein progranulin, results in a form of frontotemporal lobar degeneration that is characterized by the presence of ubiquitinated inclusions containing phosphorylated and cleaved fragments of the transactivation response element DNA-binding protein-43. This has stimulated interest in understanding the role of progranulin in the central nervous system, and in particular, how this relates to neurodegeneration. Progranulin has many roles… CONTINUE READING

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