Structurally related TPR subunits contribute differently to the function of the anaphase-promoting complex in Drosophila melanogaster.

@article{Pl2007StructurallyRT,
  title={Structurally related TPR subunits contribute differently to the function of the anaphase-promoting complex in Drosophila melanogaster.},
  author={Margit P{\'a}l and Olga Nagy and Dalma M{\'e}nesi and Andor Udvardy and P{\'e}ter De{\'a}k},
  journal={Journal of cell science},
  year={2007},
  volume={120 Pt 18},
  pages={3238-48}
}
The anaphase-promoting complex/cyclosome or APC/C is a key regulator of chromosome segregation and mitotic exit in eukaryotes. It contains at least 11 subunits, most of which are evolutionarily conserved. The most abundant constituents of the vertebrate APC/C are the four structurally related tetratrico-peptide repeat (TPR) subunits, the functions of which are not yet precisely understood. Orthologues of three of the TPR subunits have been identified in Drosophila. We have shown previously that… CONTINUE READING

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